In the history of science, new measurement techniques have created ground-breaking research fields. Following the history, Ideguchi group develops optical measurement techniques to open up new physical and biological science.

Reserach topics

Mid-infrared technology

  • Broadband or tunable mid-infrared lasers
  • World's fastest mid-infrared spectroscopy
  • Mid-infrared photothermal phase microscopy
  • Computational dual-comb spectroscopy

Nonlinear optical technology

  • World's fastest coherent Raman spectroscopy/microscopy
  • Simultaneous infrared and Raman spectroscopy
  • Multi-modal nonlinear microscopy
  • Vibrational flow-cytometry

Label-free cell biology

  • Large-scale label-free single-cell analysis
  • Label-free biophysics

Physics of laser material processing

  • Time-resolved image analysis of laser processing

Selected achievements


Dual-comb spectroscopy

Review article

Optics and Photonics News (2017)

Single-laser dual-comb spectroscopy

Optica (2016)

Adaptive dual-comb spectroscopy

Nature Communications (2014)

Coherent Raman dual-comb spectroscopy

Nature (2013)

Compressive dual-comb spectroscopy

Scientific Reports (2021) 

Phase-controlled Fourier-transform spectroscopy (PC-FTS)

Nature Communications (2018)

Complementary vibrational spectroscopy (CVS)

Nature Communications (2019)

Time-stretch infrared spectroscopy (TS-IR)

Communications Physics (2020)

Fourier-transform coherent anti-Stokes Raman scattering spectroscopy (FT-CARS) 

Optics Letters (2020)

Optics Express (2018)

Coherent Raman flow cytometry

Science Advances (2019)

Optics Letters (2018)



Mid-infrared photothermal phase microscopy

Optica (2020)

Optics Letters (2019)

Scientific Reports (2019)

Adaptive dynamic range shift quantitative phase imaging (ADRIFT-QPI)

Light: Science & Applications 10, 1 (2021)



Optical parametric oscillator

Laser & Photonics Reviews (2014)

Supercontinuum generation

Nature Communications (2015)